Added sugars drive nutrient and energy deficit in obesity: a new paradigm - PubMed

This review challenges the traditional model of obesity as a simple caloric imbalance, proposing instead that it is a state of hormonal dysregulation and nutrient deficit. The authors argue that added sugars like sucrose and high-fructose corn syrup hinder energy production and deplete essential nutrient stores. This metabolic impairment induces "internal starvation" through leptin and insulin resistance, driving increased caloric intake and decreasing physical activity. Ultimately, the paper presents a paradigm where sugar-driven mitochondrial damage and nutrient depletion are primary catalysts for fat accumulation.