Research
Defective ubiquitination of cerebral proteins in Alzheimer's disease - PubMed
A. Thomas McLellanDavid C. LewisCharles P. O'BrienHerbert D. Kleber
Research indicates that Alzheimer’s disease is linked to a significant failure in the brain's ubiquitin system, which impairs the degradation of proteins. This enzymatic breakdown may contribute to the characteristic accumulation of protein deposits in the cerebral cortex.
Alzheimer's DiseaseUbiquitinProteasomeNeurodegenerationCerebral CortexEnzymologyProtein Metabolism
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