neurobiology

Low Cortisol and ADHD: Understanding the Hidden Connection

**Low cortisol—a state of adrenal insufficiency or dysregulation—can amplify ADHD symptoms by depleting energy reserves, impairing focus, and disrupting the brain's stress-response systems.** While ADHD is primarily a dopamine-related executive function disorder, cortisol plays a critical supporting role in maintaining alertness, regulating inflammation, and modulating the body's response to daily demands. When cortisol levels drop too low, adults with ADHD often experience worsening brain fog, fatigue, and difficulty initiating tasks—creating a compounding effect that standard ADHD treatments may not fully address.